Difficulties in senior IVF: Coenzyme Q10 is ineffective? Try it to increase the clinical pregnancy rate by up to 43%!
In the reproduction centre, to say who is the most difficult, it is the elderly women, if you meet the obesity, it is even more difficult, many times unsuccessful in vitro women, we can always see their figure.
In the end, how to improve the pregnancy rate, many sisters also used a variety of methods, such as coenzyme Q10, growth hormone, etc., spent a lot of money, but the results are not satisfactory.
Proprietary Chinese medicines are a Chinese specialty, but they have been widely criticised in the clinic because there are no randomised multi-centre clinical controlled trials.
However, the medicine that Circle Sister introduces to you today has been proven to be extremely helpful in assisting conception through a randomised controlled trial of 19 fertility centres across China.
It is Nourishing Kidney and Fertilising Pill!
01 2022 Study: Significantly Improved Live Birth Rates for Fresh Transplants
This is a multi-centre, large-scale, placebo-controlled, randomised pilot study published in Obstetrics and Gynaecology, a leading American journal of obstetrics and gynaecology.
This study included 2,580 patients and from this study group 2,265 patients were randomly selected, 1,131 patients were assigned to the Zi Kidney Foetus Repairing Pill group and 1,134 patients were assigned to the placebo, with similar characteristics between the groups.
During the study, the treatment group received 5 grams of Zi Kidney Yuzui Pills and the placebo group received the same dose of placebo, administered three times a day.
The results found that the live birth rate was 26.8% and 23.0% in the Zi Ren Yu Yu Pill group and the placebo group, respectively; the implantation rate was 36.8% and 32.6%; the biochemical pregnancy rate was 35.5% and 31.1%; and the clinical pregnancy rate was 31.2% and 27.3%, respectively.
There were no significant differences in miscarriage rates or maternal or neonatal complications between the two groups.
The above suggests that Zi Kidney Foetus Repairing Pills improved the live birth rate after fresh embryo transfer compared to placebo.
The main mechanism of this is that ovulation induction may lead to ovarian hyperstimulation, which causes drastic changes in sex hormones and disrupts the physiological balance of human hormones.
After ovulation induction, asynchrony between the endometrial implantation window and embryo development may reduce endometrial receptivity and pregnancy rates.
Previous animal studies have demonstrated the potential of Zi Kidney Fertilisation Pills in improving endometrial receptivity and oocyte quality.
The main focus is to maintain proper endometrial differentiation and improve uterine receptivity and oocyte quality, thereby contributing to higher implantation rates.
02 2023 study: new subgroup analyses show greater role
This time, the study still used data from 2022, and on the basis of the overall improvement in pregnancy rates, the researchers tried to analyse subgroups to find a more precise population to benefit from the drug.
The subgroup analyses focused on two groups of women who have difficulty conceiving in fertility centres: older women and obese women, and analysed how the use of the drug affected them compared to the control group, according to the study, published in Frontiers in Endocrinology.
It was found that in elderly patients, Zi Ren Yu Yu Zui Wan significantly increased the implantation rate (30.4% vs. 22.4%) and clinical pregnancy rate (33.0% vs. 23.1%).
We can find that in elderly patients, Zi Kidney Fertilisation Pills improved the clinical pregnancy rate by 43% relative to placebo.
For overweight and obese patients, the implantation rate (37.4% vs. 28.9%), clinical pregnancy rate (34.5% vs. 25.0%) and live birth rate (29.1% vs. 20.6%) were significantly higher in the Zi Ren Yu Yu Wan group.
Similarly, we can find that for overweight and obese patients, Zi Kidney Fertilisation Pills improved the live birth rate by 41% relative to placebo.
Note that the elderly patients in this study were mainly 35-43 year olds and the overweight patients were mainly those with a BMI of 24-30, two subgroups that do not have a good outcome of assisted conception in any fertility centre.
In 2019, China developed its first clinical practice guideline on assisted reproduction strategies specifically for women of advanced age, and the guideline concluded that there is insufficient evidence for treatment recommendations and that methods to improve pregnancy outcomes in this population remain limited.
Now, then, the researchers found that implantation, biochemical pregnancy and clinical pregnancy rates were significantly higher in senior patients treated with Zi Kidney Fertilisation Pills than with placebo, which may provide new ideas for assisted reproduction strategies in senior patients.
Notably, through this study, it was found that although not statistically significant, Zi Ren Yu Yu Pill also demonstrated beneficial effects in the number of fertilised embryos and available embryos in women of advanced age.
According to the first expert consensus on weight management for overweight/obese infertile patients in China, overweight/obese infertile women are recommended to lose weight before pregnancy.
Obesity leads to a series of reproductive endocrinological changes, mainly including reduced ovarian reserve, decreased quality and quantity of oocytes and embryos, and poor endometrial receptivity, among others.
Although preconception weight loss is the most common intervention for infertile overweight/obese women, the damage to female fertility may not be completely reversed.
Therefore, Nourishing Kidney and Fetus Repairing Pills may provide a complementary therapeutic option for assisted reproductive strategies regarding overweight and obese patients.
03Theoretical basis of Chinese medicine for Nourishing Kidney and Yuking Fetus Pills
Nourishing Kidney and Yuking Fetus Pill is an empirical formula of Professor Luo Yuankai, a nationally renowned Chinese medicine practitioner, which has been rated as a national protected variety of traditional Chinese medicine and is now in the National Essential Drugs Catalogue.
In Chinese medicine theory, the kidney is the main reproductive organ, is the foundation of the innate nature, and hides the essence of the cell, the kidney qi is weak, the impulses are not solid, the foetus loses the system, which can lead to the occurrence of preeclampsia and habitual miscarriage.
Clinical studies have shown that kidney deficiency or spleen and kidney deficiency is the main type of preeclampsia, accounting for 88.04% of cases.
The main pathogenesis of recurrent spontaneous abortion or habitual abortion is kidney deficiency and qi and blood weakness.
Judging from the principle of the formula and the composition of the drug, Zi Kidney Foetus Repairing Pill can be applied to preeclampsia and recurrent spontaneous abortion with kidney deficiency, spleen deficiency, qi and blood deficiency or spleen and kidney deficiency.
The key to pregnancy is the prevalence of kidney qi. If the kidney qi is insufficient, the Chong Ren can’t be funded, and the qi and blood are out of balance, it will be difficult to conceive.
Kidney deficiency can be due to congenital deficiency of kidney qi or acquired injury, and kidney yin deficiency and kidney yang deficiency can occur due to the yin and yang bias of the body and the influence of pathological causes.
The prevalence of kidney qi plays an important role in the success or failure of IVF. After IVF, the foetus is already knotted, and the retention of the foetus depends on the prevalence of the kidneys.
If the kidneys are full of vital energy, and there is enough Chong Ren, the foetus will be nourished and kept, then it will be easy to stay and grow; if the kidneys are deficient in vital energy, and the Chong Ren is insufficient, the foetus will be deprived of nourishment, then it will be easy to abort and difficult to stay.
Generally speaking, it is necessary to start taking it orally on the fifth day of the week, which is conducive to increasing the number of high-quality eggs and improving the clinical pregnancy rate.
For patients with previous IVF failure, Zi Kidney Foetus Repairing Pills can be taken for 3 menstrual cycles (discontinued on days 1-4 of menstruation) before egg retrieval or frozen embryo transfer again.
In conclusion, through the two clinical studies of these data, we can find that Zi Kidney Foetus Yuking Pills have a significant effect on the pregnancy rate of fresh IVF cycle transfer, and the second study further pinpointed the largest beneficiary population.
However, the current study sample is still somewhat insufficient, the elderly population is the most difficult to gnaw the hard bone of the fertility centre, further research on the elderly population may bring more gains, we can look forward to together!
